Drug interactions
Indacaterol + Methadone
Severity: Moderate
Indacaterol and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone is associated with QT prolongation and torsades de pointes, and indacaterol may add to the risk through hypokalemia and heart rate increases.
What this interaction means in plain words
Indacaterol and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation with beta-2 agonist-induced hypokalemia.
What to do
Monitor ECG and potassium, particularly with higher methadone doses or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Indacaterol with Methadone?
MediHelp rates the interaction as moderate. Indacaterol and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methadone is associated with QT prolongation and torsades de pointes, and indacaterol may add to the risk through hypokalemia and heart rate increases.
How serious is the interaction between Indacaterol and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium, particularly with higher methadone doses or other QT-prolonging drugs.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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