Drug interactions
Indacaterol + Nilotinib
Severity: Major
Indacaterol and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib carries a boxed warning for QT prolongation and sudden death, and indacaterol may add to arrhythmic risk through hypokalemia and heart rate effects. Nilotinib also inhibits CYP3A4 and P-gp, which may raise indacaterol exposure.
What this interaction means in plain words
Indacaterol and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Nilotinib belongs to Oncology.
Why it happens
Additive QT prolongation and beta-agonist hypokalemia, plus CYP3A4/P-gp inhibition.
What to do
Obtain a baseline ECG, keep potassium and magnesium normal, and repeat ECG monitoring during co-therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Indacaterol with Nilotinib?
MediHelp rates the interaction as major. Indacaterol and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib carries a boxed warning for QT prolongation and sudden death, and indacaterol may add to arrhythmic risk through hypokalemia and heart rate effects. Nilotinib also inhibits CYP3A4 and P-gp, which may raise indacaterol exposure.
How serious is the interaction between Indacaterol and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, keep potassium and magnesium normal, and repeat ECG monitoring during co-therapy.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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