Drug interactions
Indacaterol + Phenelzine
Severity: Major
Indacaterol and Phenelzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, leading to palpitations, blood pressure changes and arrhythmias. Labeling advises extreme caution when indacaterol is used with an MAO inhibitor.
What this interaction means in plain words
Indacaterol and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition raises catecholamine levels and potentiates the sympathomimetic vascular and cardiac effects of indacaterol.
What to do
Avoid the combination where possible, or use it only with close monitoring of heart rate, blood pressure and ECG. Consider an alternative bronchodilator regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Indacaterol with Phenelzine?
MediHelp rates the interaction as major. Indacaterol and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, leading to palpitations, blood pressure changes and arrhythmias. Labeling advises extreme caution when indacaterol is used with an MAO inhibitor.
How serious is the interaction between Indacaterol and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use it only with close monitoring of heart rate, blood pressure and ECG. Consider an alternative bronchodilator regimen.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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