Drug interactions
Indacaterol + Selpercatinib
Severity: Moderate
Indacaterol and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and indacaterol may add to cardiac repolarization effects and lower potassium. The combination may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Indacaterol and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation and beta-agonist induced hypokalemia.
What to do
Monitor ECG and correct potassium and magnesium abnormalities. Reassess the combination if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Selpercatinib
Frequently asked questions
Can I take Indacaterol with Selpercatinib?
MediHelp rates the interaction as moderate. Indacaterol and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, and indacaterol may add to cardiac repolarization effects and lower potassium. The combination may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Indacaterol and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium abnormalities. Reassess the combination if QTc rises significantly.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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