Drug interactions
Indacaterol + Timolol
Severity: Major
Indacaterol and Timolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol is a nonselective beta-blocker, and even ophthalmic use can be absorbed enough to cause bronchospasm in susceptible patients and blunt indacaterol's effect.
What this interaction means in plain words
Indacaterol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Timolol belongs to Cardiovascular.
Why it happens
Competitive antagonism at beta-2 receptors by a nonselective beta-blocker.
What to do
Avoid timolol in patients with COPD or asthma and use a non-beta-blocker alternative, especially for glaucoma. If essential, monitor respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Indacaterol with Timolol?
MediHelp rates the interaction as major. Indacaterol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Timolol is a nonselective beta-blocker, and even ophthalmic use can be absorbed enough to cause bronchospasm in susceptible patients and blunt indacaterol's effect.
How serious is the interaction between Indacaterol and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid timolol in patients with COPD or asthma and use a non-beta-blocker alternative, especially for glaucoma. If essential, monitor respiratory function.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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