Drug interactions
Indacaterol-glycopyrronium + Isoproterenol
Severity: Major
Indacaterol-glycopyrronium and Isoproterenol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol is a nonselective beta agonist, and combining it with indacaterol duplicates beta-adrenergic stimulation. This can cause tachycardia, tremor, arrhythmias and hypokalemia.
What this interaction means in plain words
Indacaterol-glycopyrronium and Isoproterenol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Isoproterenol belongs to Respiratory.
Why it happens
Additive beta-adrenergic receptor agonism.
What to do
Avoid concurrent use of other beta agonists where possible. If isoproterenol is required, monitor heart rate, ECG and serum potassium closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Isoproterenol
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Isoproterenol?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Isoproterenol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isoproterenol is a nonselective beta agonist, and combining it with indacaterol duplicates beta-adrenergic stimulation. This can cause tachycardia, tremor, arrhythmias and hypokalemia.
How serious is the interaction between Indacaterol-glycopyrronium and Isoproterenol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of other beta agonists where possible. If isoproterenol is required, monitor heart rate, ECG and serum potassium closely.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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