Drug interactions
Indacaterol-glycopyrronium + Lapatinib
Severity: Moderate
Indacaterol-glycopyrronium and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and P-gp and may modestly raise indacaterol exposure. Lapatinib also prolongs the QT interval, so combined arrhythmic risk may be additive.
What this interaction means in plain words
Indacaterol-glycopyrronium and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Lapatinib belongs to Oncology.
Why it happens
P-gp and CYP3A4 inhibition increases indacaterol levels, with additive QT prolongation.
What to do
Monitor ECG and electrolytes in patients with cardiac risk factors. Correct hypokalemia and hypomagnesemia before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Lapatinib?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and P-gp and may modestly raise indacaterol exposure. Lapatinib also prolongs the QT interval, so combined arrhythmic risk may be additive.
How serious is the interaction between Indacaterol-glycopyrronium and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac risk factors. Correct hypokalemia and hypomagnesemia before and during therapy.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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