Drug interactions
Indacaterol-glycopyrronium + Levofloxacin
Severity: Moderate
Indacaterol-glycopyrronium and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can prolong the QT interval, and indacaterol may add to cardiac repolarization effects and lower potassium. The combination may raise the risk of ventricular arrhythmia.
What this interaction means in plain words
Indacaterol-glycopyrronium and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia.
What to do
Consider ECG monitoring in patients with cardiac disease or electrolyte disturbance. Correct hypokalemia and hypomagnesemia, or choose a non-QT-prolonging antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Levofloxacin?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can prolong the QT interval, and indacaterol may add to cardiac repolarization effects and lower potassium. The combination may raise the risk of ventricular arrhythmia.
How serious is the interaction between Indacaterol-glycopyrronium and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider ECG monitoring in patients with cardiac disease or electrolyte disturbance. Correct hypokalemia and hypomagnesemia, or choose a non-QT-prolonging antibiotic.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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