Drug interactions
Indacaterol-glycopyrronium + Loxapine
Severity: Moderate
Indacaterol-glycopyrronium and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has anticholinergic properties that add to glycopyrronium, increasing risks of dry mouth, constipation, urinary retention and blurred vision. Loxapine may also affect QT and bronchospasm risk is a concern with inhaled loxapine.
What this interaction means in plain words
Indacaterol-glycopyrronium and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects, with possible additive QT effects.
What to do
Monitor for anticholinergic effects such as urinary retention and constipation, especially in older adults. Reduce other anticholinergic load where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Loxapine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has anticholinergic properties that add to glycopyrronium, increasing risks of dry mouth, constipation, urinary retention and blurred vision. Loxapine may also affect QT and bronchospasm risk is a concern with inhaled loxapine.
How serious is the interaction between Indacaterol-glycopyrronium and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention and constipation, especially in older adults. Reduce other anticholinergic load where possible.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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