Drug interactions
Indacaterol-glycopyrronium + Maprotiline
Severity: Moderate
Indacaterol-glycopyrronium and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a tetracyclic antidepressant with anticholinergic activity and QT-prolonging potential. With indacaterol-glycopyrronium it may increase anticholinergic effects and cardiac arrhythmia risk.
What this interaction means in plain words
Indacaterol-glycopyrronium and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive anticholinergic effects and additive QT prolongation or adrenergic cardiac effects.
What to do
Monitor ECG in patients with cardiac risk factors and watch for urinary retention or constipation. Consider a less anticholinergic antidepressant if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Maprotiline?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a tetracyclic antidepressant with anticholinergic activity and QT-prolonging potential. With indacaterol-glycopyrronium it may increase anticholinergic effects and cardiac arrhythmia risk.
How serious is the interaction between Indacaterol-glycopyrronium and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and watch for urinary retention or constipation. Consider a less anticholinergic antidepressant if needed.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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