Drug interactions
Indacaterol-glycopyrronium + Nadolol
Severity: Major
Indacaterol-glycopyrronium and Nadolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a nonselective beta-blocker that directly opposes indacaterol and can cause severe bronchospasm in patients with obstructive airway disease. Bronchodilator benefit may be lost.
What this interaction means in plain words
Indacaterol-glycopyrronium and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Nadolol belongs to Cardiovascular.
Why it happens
Nonselective beta-2 receptor blockade antagonizes beta-2 agonist bronchodilation.
What to do
Avoid nonselective beta-blockers in patients using indacaterol; use a cardioselective agent if a beta-blocker is essential. Monitor respiratory function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Nadolol?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a nonselective beta-blocker that directly opposes indacaterol and can cause severe bronchospasm in patients with obstructive airway disease. Bronchodilator benefit may be lost.
How serious is the interaction between Indacaterol-glycopyrronium and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta-blockers in patients using indacaterol; use a cardioselective agent if a beta-blocker is essential. Monitor respiratory function closely.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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