Drug interactions
Indacaterol-glycopyrronium + Nebivolol
Severity: Moderate
Indacaterol-glycopyrronium and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is a highly cardioselective beta-blocker, but it can still blunt indacaterol's effect and cause bronchospasm at higher doses. The risk is lower than with nonselective agents.
What this interaction means in plain words
Indacaterol-glycopyrronium and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Nebivolol belongs to Cardiovascular.
Why it happens
Beta-receptor antagonism opposing beta-2 agonist bronchodilation, with selectivity lost at higher doses.
What to do
Use the lowest effective nebivolol dose and monitor respiratory symptoms and lung function. Reassess if bronchospasm or reduced bronchodilator response occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Nebivolol?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol is a highly cardioselective beta-blocker, but it can still blunt indacaterol's effect and cause bronchospasm at higher doses. The risk is lower than with nonselective agents.
How serious is the interaction between Indacaterol-glycopyrronium and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective nebivolol dose and monitor respiratory symptoms and lung function. Reassess if bronchospasm or reduced bronchodilator response occurs.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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