Drug interactions
Indacaterol-glycopyrronium + Pilocarpine
Severity: Moderate
Indacaterol-glycopyrronium and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist and glycopyrronium is a muscarinic antagonist, so they oppose one another. Pilocarpine's effect on salivation or other cholinergic actions may be reduced.
What this interaction means in plain words
Indacaterol-glycopyrronium and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Pilocarpine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced pilocarpine efficacy and adjust the dose if needed. Consider whether the antimuscarinic bronchodilator is essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Pilocarpine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist and glycopyrronium is a muscarinic antagonist, so they oppose one another. Pilocarpine's effect on salivation or other cholinergic actions may be reduced.
How serious is the interaction between Indacaterol-glycopyrronium and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced pilocarpine efficacy and adjust the dose if needed. Consider whether the antimuscarinic bronchodilator is essential.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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