Drug interactions
Indacaterol-glycopyrronium + Propafenone
Severity: Moderate
Indacaterol-glycopyrronium and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone can prolong QRS and QT intervals and has proarrhythmic potential. Indacaterol may add to QT effects and lower potassium, and propafenone's beta-blocking activity may blunt bronchodilation.
What this interaction means in plain words
Indacaterol-glycopyrronium and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Propafenone belongs to Cardiovascular.
Why it happens
Additive QT effects and pharmacodynamic antagonism via propafenone's beta-blocking activity.
What to do
Monitor ECG and potassium and watch for loss of bronchodilator effect or bronchospasm. Consider an alternative antiarrhythmic in patients with significant airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Propafenone?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone can prolong QRS and QT intervals and has proarrhythmic potential. Indacaterol may add to QT effects and lower potassium, and propafenone's beta-blocking activity may blunt bronchodilation.
How serious is the interaction between Indacaterol-glycopyrronium and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium and watch for loss of bronchodilator effect or bronchospasm. Consider an alternative antiarrhythmic in patients with significant airway disease.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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