Drug interactions
Indacaterol-glycopyrronium + Quinidine
Severity: Major
Indacaterol-glycopyrronium and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a well-known QT-prolonging drug with a risk of torsades de pointes, and indacaterol may add to QT effects and lower potassium. Quinidine also has anticholinergic activity and inhibits P-gp.
What this interaction means in plain words
Indacaterol-glycopyrronium and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, beta-2 agonist-associated hypokalemia and additive antimuscarinic effects.
What to do
Obtain baseline and follow-up ECGs and maintain normal potassium and magnesium. Consider an alternative bronchodilator or antiarrhythmic if QTc lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Quinidine?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine is a well-known QT-prolonging drug with a risk of torsades de pointes, and indacaterol may add to QT effects and lower potassium. Quinidine also has anticholinergic activity and inhibits P-gp.
How serious is the interaction between Indacaterol-glycopyrronium and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and follow-up ECGs and maintain normal potassium and magnesium. Consider an alternative bronchodilator or antiarrhythmic if QTc lengthens.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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