Drug interactions
Indacaterol-glycopyrronium + Ritonavir
Severity: Moderate
Indacaterol-glycopyrronium and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and P-glycoprotein and can raise indacaterol exposure, which may increase beta-agonist effects. Ritonavir can also prolong the QT interval, so combined use may add to arrhythmic risk.
What this interaction means in plain words
Indacaterol-glycopyrronium and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces indacaterol clearance, plus additive QT effects.
What to do
Use the standard dose and monitor heart rate, potassium and ECG if symptoms or risk factors for QT prolongation exist. Reduce exposure or review therapy if beta-agonist adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Ritonavir?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir strongly inhibits CYP3A4 and P-glycoprotein and can raise indacaterol exposure, which may increase beta-agonist effects. Ritonavir can also prolong the QT interval, so combined use may add to arrhythmic risk.
How serious is the interaction between Indacaterol-glycopyrronium and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the standard dose and monitor heart rate, potassium and ECG if symptoms or risk factors for QT prolongation exist. Reduce exposure or review therapy if beta-agonist adverse effects develop.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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