Drug interactions
Indacaterol-glycopyrronium + Tranylcypromine
Severity: Major
Indacaterol-glycopyrronium and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may potentiate the cardiovascular effects of beta2-agonists, leading to tachycardia, hypertension, palpitations or arrhythmias. Labeling advises extreme caution with MAO inhibitors and for about two weeks after stopping them.
What this interaction means in plain words
Indacaterol-glycopyrronium and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Why it happens
Potentiation of adrenergic cardiovascular effects, with possible additive QT effects.
What to do
Avoid if possible; if used, monitor blood pressure, heart rate and rhythm closely, especially after dose changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Tranylcypromine?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors may potentiate the cardiovascular effects of beta2-agonists, leading to tachycardia, hypertension, palpitations or arrhythmias. Labeling advises extreme caution with MAO inhibitors and for about two weeks after stopping them.
How serious is the interaction between Indacaterol-glycopyrronium and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, monitor blood pressure, heart rate and rhythm closely, especially after dose changes.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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