Drug interactions
Indacaterol-glycopyrronium + Verapamil
Severity: Minor
Indacaterol-glycopyrronium and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-glycoprotein and CYP3A4, which can raise indacaterol exposure. Pharmacokinetic studies showed only a modest increase and no dose adjustment is needed at standard doses.
What this interaction means in plain words
Indacaterol-glycopyrronium and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indacaterol-glycopyrronium belongs to Respiratory; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein and CYP3A4 reduces indacaterol clearance.
What to do
No dose adjustment is required. Monitor for beta2-agonist effects such as tremor, palpitations and hypokalemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Verapamil?
MediHelp rates the interaction as minor. Indacaterol-glycopyrronium and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil inhibits P-glycoprotein and CYP3A4, which can raise indacaterol exposure. Pharmacokinetic studies showed only a modest increase and no dose adjustment is needed at standard doses.
How serious is the interaction between Indacaterol-glycopyrronium and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for beta2-agonist effects such as tremor, palpitations and hypokalemia.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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