Drug interactions
Indacaterol-glycopyrronium + Voclosporin
Severity: Moderate
Indacaterol-glycopyrronium and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval at supratherapeutic exposures, and indacaterol may add to arrhythmic risk. Clinical significance is likely small at usual doses but matters in patients with cardiac risk factors.
What this interaction means in plain words
Indacaterol-glycopyrronium and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Voclosporin belongs to Miscellaneous.
Why it happens
Additive effects on cardiac repolarization; beta-2 agonist effects include possible hypokalemia.
What to do
Monitor ECG and electrolytes in patients with cardiac risk factors or other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Voclosporin?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QT interval at supratherapeutic exposures, and indacaterol may add to arrhythmic risk. Clinical significance is likely small at usual doses but matters in patients with cardiac risk factors.
How serious is the interaction between Indacaterol-glycopyrronium and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac risk factors or other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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