Drug interactions
Indacaterol-glycopyrronium + Ziprasidone
Severity: Moderate
Indacaterol-glycopyrronium and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone prolongs the QT interval, and indacaterol, a beta-2 agonist, can also affect repolarization and lower potassium. Together they may raise the risk of ventricular arrhythmias, especially in patients with other risk factors. Ziprasidone also has some anticholinergic activity that may add to glycopyrronium effects.
What this interaction means in plain words
Indacaterol-glycopyrronium and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QTc prolongation (ziprasidone with beta-2 agonist effects on repolarization and potassium) plus minor additive anticholinergic effects.
What to do
Obtain a baseline ECG and check potassium and magnesium in patients with cardiac risk factors, and correct any deficits. Monitor for palpitations, syncope or QTc lengthening and review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Ziprasidone?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone prolongs the QT interval, and indacaterol, a beta-2 agonist, can also affect repolarization and lower potassium. Together they may raise the risk of ventricular arrhythmias, especially in patients with other risk factors. Ziprasidone also has some anticholinergic activity that may add to glycopyrronium effects.
How serious is the interaction between Indacaterol-glycopyrronium and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and check potassium and magnesium in patients with cardiac risk factors, and correct any deficits. Monitor for palpitations, syncope or QTc lengthening and review other QT-prolonging drugs.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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