Drug interactions
Indacaterol inhaled + Posaconazole
Severity: Moderate
Indacaterol inhaled and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a long-acting beta agonist, can prolong the QT interval, and posaconazole also prolongs QT. Posaconazole may also modestly raise indacaterol exposure, increasing the risk of arrhythmia.
What this interaction means in plain words
Indacaterol inhaled and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, along with possible inhibition of CYP3A4 and P-gp clearance of indacaterol by posaconazole.
What to do
Monitor ECG and electrolytes, especially in patients with cardiac disease. Watch for palpitations, tremor and hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Posaconazole?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a long-acting beta agonist, can prolong the QT interval, and posaconazole also prolongs QT. Posaconazole may also modestly raise indacaterol exposure, increasing the risk of arrhythmia.
How serious is the interaction between Indacaterol inhaled and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, especially in patients with cardiac disease. Watch for palpitations, tremor and hypokalemia.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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