Drug interactions
Indapamide + Pentamidine
Severity: Major
Indapamide and Pentamidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can prolong the QT interval and cause torsades de pointes, and may also cause hypoglycemia and electrolyte disturbances. Indapamide-induced hypokalemia or hypomagnesemia increases the arrhythmia risk.
What this interaction means in plain words
Indapamide and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indapamide belongs to Cardiovascular; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation with diuretic-induced electrolyte depletion.
What to do
Check and correct potassium and magnesium and monitor ECG during pentamidine therapy. Consider holding indapamide during systemic pentamidine treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Indapamide with Pentamidine?
MediHelp rates the interaction as major. Indapamide and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentamidine can prolong the QT interval and cause torsades de pointes, and may also cause hypoglycemia and electrolyte disturbances. Indapamide-induced hypokalemia or hypomagnesemia increases the arrhythmia risk.
How serious is the interaction between Indapamide and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium and monitor ECG during pentamidine therapy. Consider holding indapamide during systemic pentamidine treatment.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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