Drug interactions
Indapamide + Posaconazole
Severity: Moderate
Indapamide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can cause hypokalemia and hypomagnesemia and has been associated with QT prolongation. Together with posaconazole, this increases the risk of torsades de pointes.
What this interaction means in plain words
Indapamide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT effects, worsened by diuretic-induced electrolyte depletion.
What to do
Monitor serum potassium and magnesium and replace them as needed. Obtain an ECG if other QT risk factors are present or consider an alternative antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Posaconazole?
MediHelp rates the interaction as moderate. Indapamide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide can cause hypokalemia and hypomagnesemia and has been associated with QT prolongation. Together with posaconazole, this increases the risk of torsades de pointes.
How serious is the interaction between Indapamide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and replace them as needed. Obtain an ECG if other QT risk factors are present or consider an alternative antihypertensive.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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