Drug interactions
Indinavir + Ivermectin
Severity: Minor
Indinavir and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and P-glycoprotein and may raise ivermectin levels. Clinical consequences are expected to be limited given ivermectin's wide safety margin.
What this interaction means in plain words
Indinavir and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Indinavir inhibits CYP3A4 metabolism and P-glycoprotein efflux of ivermectin.
What to do
No routine adjustment is needed. Monitor for CNS effects or other adverse effects if high or repeated ivermectin doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Frequently asked questions
Can I take Indinavir with Ivermectin?
MediHelp rates the interaction as minor. Indinavir and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4 and P-glycoprotein and may raise ivermectin levels. Clinical consequences are expected to be limited given ivermectin's wide safety margin.
How serious is the interaction between Indinavir and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for CNS effects or other adverse effects if high or repeated ivermectin doses are used.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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