Drug interactions
Indinavir + Medroxyprogesterone
Severity: Moderate
Indinavir and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may increase medroxyprogesterone concentrations. Progestin adverse effects may be more pronounced, although the effect is largely predicted rather than well documented.
What this interaction means in plain words
Indinavir and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of medroxyprogesterone by indinavir.
What to do
Monitor for progestogenic adverse effects such as bleeding changes, fluid retention and glucose intolerance. Adjust the hormonal regimen if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Indinavir with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Indinavir and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may increase medroxyprogesterone concentrations. Progestin adverse effects may be more pronounced, although the effect is largely predicted rather than well documented.
How serious is the interaction between Indinavir and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects such as bleeding changes, fluid retention and glucose intolerance. Adjust the hormonal regimen if these occur.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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