Drug interactions
Indinavir + Posaconazole
Severity: Moderate
Indinavir and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases indinavir concentrations, which may raise the risk of indinavir toxicity such as nephrolithiasis and hyperbilirubinemia. Indinavir may modestly affect posaconazole levels.
What this interaction means in plain words
Indinavir and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of indinavir, and indinavir may inhibit P-gp efflux of posaconazole.
What to do
Monitor for indinavir toxicity, including hematuria and flank pain, and ensure adequate hydration. Consider reducing the indinavir dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Indinavir with Posaconazole?
MediHelp rates the interaction as moderate. Indinavir and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole increases indinavir concentrations, which may raise the risk of indinavir toxicity such as nephrolithiasis and hyperbilirubinemia. Indinavir may modestly affect posaconazole levels.
How serious is the interaction between Indinavir and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for indinavir toxicity, including hematuria and flank pain, and ensure adequate hydration. Consider reducing the indinavir dose.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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