Drug interactions
Indomethacin + Labetalol
Severity: Moderate
Indomethacin and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular indomethacin use can blunt the antihypertensive effect of labetalol. Blood pressure may rise after NSAID initiation.
What this interaction means in plain words
Indomethacin and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Labetalol belongs to Cardiovascular.
Why it happens
NSAIDs reduce vasodilatory prostaglandin synthesis and cause sodium and fluid retention.
What to do
Monitor blood pressure during concomitant use, particularly beyond one week. Adjust the antihypertensive regimen or consider a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Indomethacin with Labetalol?
MediHelp rates the interaction as moderate. Indomethacin and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular indomethacin use can blunt the antihypertensive effect of labetalol. Blood pressure may rise after NSAID initiation.
How serious is the interaction between Indomethacin and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during concomitant use, particularly beyond one week. Adjust the antihypertensive regimen or consider a non-NSAID analgesic.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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