Drug interactions
Indomethacin + Lornoxicam
Severity: Major
Indomethacin and Lornoxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two NSAIDs together offers no added analgesic benefit and increases the risk of gastrointestinal bleeding, ulceration, and kidney injury. Cardiovascular risk may also be additive.
What this interaction means in plain words
Indomethacin and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indomethacin belongs to Musculoskeletal; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive COX-1 and COX-2 inhibition causing mucosal injury, platelet inhibition, and reduced renal prostaglandins.
What to do
Avoid concurrent use of two systemic NSAIDs and use a single agent at the lowest effective dose. Switch fully before starting the other.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Indomethacin with Lornoxicam?
MediHelp rates the interaction as major. Indomethacin and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two NSAIDs together offers no added analgesic benefit and increases the risk of gastrointestinal bleeding, ulceration, and kidney injury. Cardiovascular risk may also be additive.
How serious is the interaction between Indomethacin and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two systemic NSAIDs and use a single agent at the lowest effective dose. Switch fully before starting the other.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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