Drug interactions
Indomethacin + Pegaspargase
Severity: Moderate
Indomethacin and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can cause coagulation abnormalities including reduced fibrinogen and other clotting factors, as well as thrombosis. NSAIDs inhibit platelet function, so the combination may raise bleeding risk.
What this interaction means in plain words
Indomethacin and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Additive hemostatic impairment: asparaginase-induced coagulation factor deficiency plus NSAID antiplatelet effect.
What to do
Avoid NSAIDs when possible during pegaspargase therapy, especially with thrombocytopenia or abnormal coagulation, and monitor coagulation parameters and platelet count.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Indomethacin with Pegaspargase?
MediHelp rates the interaction as moderate. Indomethacin and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can cause coagulation abnormalities including reduced fibrinogen and other clotting factors, as well as thrombosis. NSAIDs inhibit platelet function, so the combination may raise bleeding risk.
How serious is the interaction between Indomethacin and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs when possible during pegaspargase therapy, especially with thrombocytopenia or abnormal coagulation, and monitor coagulation parameters and platelet count.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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