Drug interactions
Indomethacin + Peginterferon alfa 2b
Severity: Minor
Indomethacin and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2b may alter the metabolism of some CYP substrates, and indomethacin is mainly cleared by glucuronidation and demethylation with limited CYP2C9 involvement. A clinically meaningful change in indomethacin exposure is not well established.
What this interaction means in plain words
Indomethacin and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Interferons can modestly suppress some hepatic CYP activity, but the effect on indomethacin is theoretical.
What to do
No dose adjustment is usually needed; monitor for changes in analgesic response or NSAID adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Peginterferon alfa 2b
Frequently asked questions
Can I take Indomethacin with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Indomethacin and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa-2b may alter the metabolism of some CYP substrates, and indomethacin is mainly cleared by glucuronidation and demethylation with limited CYP2C9 involvement. A clinically meaningful change in indomethacin exposure is not well established.
How serious is the interaction between Indomethacin and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for changes in analgesic response or NSAID adverse effects.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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