Drug interactions
Indomethacin + Potassium iodide
Severity: Minor
Indomethacin and Potassium iodide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide supplies a potassium load, and indomethacin can reduce renal potassium excretion. Together they may raise serum potassium, particularly in patients with renal impairment or other hyperkalemia risks.
What this interaction means in plain words
Indomethacin and Potassium iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Potassium iodide belongs to Endocrine.
Why it happens
Indomethacin suppresses renin and aldosterone via reduced prostaglandin synthesis, decreasing renal potassium excretion in addition to the potassium delivered by potassium iodide.
What to do
Check serum potassium and renal function if used together for more than a short course, especially in patients with kidney disease or taking other potassium-raising drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Indomethacin with Potassium iodide?
MediHelp rates the interaction as minor. Indomethacin and Potassium iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Potassium iodide supplies a potassium load, and indomethacin can reduce renal potassium excretion. Together they may raise serum potassium, particularly in patients with renal impairment or other hyperkalemia risks.
How serious is the interaction between Indomethacin and Potassium iodide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function if used together for more than a short course, especially in patients with kidney disease or taking other potassium-raising drugs.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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