Drug interactions
Indomethacin + Succinylcholine
Severity: Minor
Indomethacin and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise potassium, but the contribution of indomethacin is small and no meaningful clinical interaction is established with a single anesthetic dose of succinylcholine.
What this interaction means in plain words
Indomethacin and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Succinylcholine belongs to Musculoskeletal.
Why it happens
Succinylcholine releases potassium from muscle, and NSAIDs may modestly reduce renal potassium excretion; the combined effect is theoretical.
What to do
No specific action is needed in most patients; check potassium beforehand in those with renal impairment or other hyperkalemia risks.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Indomethacin with Succinylcholine?
MediHelp rates the interaction as minor. Indomethacin and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can raise potassium, but the contribution of indomethacin is small and no meaningful clinical interaction is established with a single anesthetic dose of succinylcholine.
How serious is the interaction between Indomethacin and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed in most patients; check potassium beforehand in those with renal impairment or other hyperkalemia risks.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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