Drug interactions
Indomethacin + Torsemide
Severity: Moderate
Indomethacin and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can blunt the diuretic and natriuretic response to torsemide and may reduce its antihypertensive effect. In volume-depleted or susceptible patients the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Indomethacin and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, causing sodium and water retention and reducing renal blood flow, which opposes loop diuretic action.
What to do
Monitor blood pressure, fluid status, weight and serum creatinine and electrolytes, and increase the diuretic dose if needed. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Torsemide
Frequently asked questions
Can I take Indomethacin with Torsemide?
MediHelp rates the interaction as moderate. Indomethacin and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can blunt the diuretic and natriuretic response to torsemide and may reduce its antihypertensive effect. In volume-depleted or susceptible patients the combination also raises the risk of acute kidney injury.
How serious is the interaction between Indomethacin and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, weight and serum creatinine and electrolytes, and increase the diuretic dose if needed. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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