Drug interactions
Infliximab + Mechlorethamine
Severity: Major
Infliximab and Mechlorethamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mechlorethamine is a myelosuppressive alkylating agent, and infliximab adds immunosuppression. Together they may increase the risk of serious infection. Topical use has little systemic effect, but systemic use is significant.
What this interaction means in plain words
Infliximab and Mechlorethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Infliximab belongs to Musculoskeletal; Mechlorethamine belongs to Oncology.
Why it happens
Additive immunosuppression from cytotoxic myelosuppression and TNF-alpha blockade.
What to do
Monitor blood counts and for signs of infection, and consider holding infliximab during myelosuppressive chemotherapy. Use antimicrobial prophylaxis as indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Infliximab with Mechlorethamine?
MediHelp rates the interaction as major. Infliximab and Mechlorethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mechlorethamine is a myelosuppressive alkylating agent, and infliximab adds immunosuppression. Together they may increase the risk of serious infection. Topical use has little systemic effect, but systemic use is significant.
How serious is the interaction between Infliximab and Mechlorethamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection, and consider holding infliximab during myelosuppressive chemotherapy. Use antimicrobial prophylaxis as indicated.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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