Drug interactions
Infliximab + Ponesimod
Severity: Moderate
Infliximab and Ponesimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponesimod lowers circulating lymphocyte counts by sequestering them in lymphoid tissue, and infliximab adds TNF-alpha blockade. Combined use may increase susceptibility to infection.
What this interaction means in plain words
Infliximab and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Infliximab belongs to Musculoskeletal; Ponesimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression: S1P receptor modulation with lymphocyte sequestration plus TNF-alpha inhibition.
What to do
Monitor for infection and check lymphocyte counts while on both drugs. Consider infliximab's prolonged immune effects when starting or switching therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Infliximab with Ponesimod?
MediHelp rates the interaction as moderate. Infliximab and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponesimod lowers circulating lymphocyte counts by sequestering them in lymphoid tissue, and infliximab adds TNF-alpha blockade. Combined use may increase susceptibility to infection.
How serious is the interaction between Infliximab and Ponesimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check lymphocyte counts while on both drugs. Consider infliximab's prolonged immune effects when starting or switching therapy.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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