Drug interactions
Infliximab + Siponimod
Severity: Moderate
Infliximab and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod reduces peripheral lymphocyte counts, and infliximab blocks TNF-alpha. Together they may increase the risk of serious infection.
What this interaction means in plain words
Infliximab and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Infliximab belongs to Musculoskeletal; Siponimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression from S1P receptor modulation with lymphocyte sequestration and TNF-alpha inhibition.
What to do
Monitor for infection and lymphocyte counts during combined use. Account for the prolonged immune effects of infliximab when switching or overlapping therapies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Infliximab with Siponimod?
MediHelp rates the interaction as moderate. Infliximab and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod reduces peripheral lymphocyte counts, and infliximab blocks TNF-alpha. Together they may increase the risk of serious infection.
How serious is the interaction between Infliximab and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and lymphocyte counts during combined use. Account for the prolonged immune effects of infliximab when switching or overlapping therapies.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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