Drug interactions
Infliximab + Tisagenlecleucel
Severity: Major
Infliximab and Tisagenlecleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tisagenlecleucel recipients are already at risk of prolonged cytopenias and infections, and infliximab adds immunosuppression. Immunosuppressants may also affect CAR-T expansion and persistence, although TNF blockers are sometimes used for toxicity management.
What this interaction means in plain words
Infliximab and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Infliximab belongs to Musculoskeletal; Tisagenlecleucel belongs to Oncology.
Why it happens
Additive immunosuppression and potential impairment of CAR-T cell function and expansion.
What to do
Avoid planned infliximab around lymphodepletion and infusion unless clearly needed. Monitor for infection and cytopenias if it is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Infliximab with Tisagenlecleucel?
MediHelp rates the interaction as major. Infliximab and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tisagenlecleucel recipients are already at risk of prolonged cytopenias and infections, and infliximab adds immunosuppression. Immunosuppressants may also affect CAR-T expansion and persistence, although TNF blockers are sometimes used for toxicity management.
How serious is the interaction between Infliximab and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid planned infliximab around lymphodepletion and infusion unless clearly needed. Monitor for infection and cytopenias if it is required.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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