Drug interactions
Infliximab + Trastuzumab
Severity: Minor
Infliximab and Trastuzumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab has no major immunosuppressive effect alone, but it can increase neutropenia when given with myelosuppressive chemotherapy. Any additive infection risk with infliximab is mostly theoretical and depends on concurrent chemotherapy and disease state.
What this interaction means in plain words
Infliximab and Trastuzumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Infliximab belongs to Musculoskeletal; Trastuzumab belongs to Oncology.
Why it happens
No established direct interaction; any added infection risk is from TNF blockade combined with possible neutropenia.
What to do
Monitor neutrophil counts and signs of infection, particularly when chemotherapy is also given. No dose change is needed routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Infliximab with Trastuzumab?
MediHelp rates the interaction as minor. Infliximab and Trastuzumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trastuzumab has no major immunosuppressive effect alone, but it can increase neutropenia when given with myelosuppressive chemotherapy. Any additive infection risk with infliximab is mostly theoretical and depends on concurrent chemotherapy and disease state.
How serious is the interaction between Infliximab and Trastuzumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection, particularly when chemotherapy is also given. No dose change is needed routinely.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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