Drug interactions
Infliximab + Ublituximab
Severity: Moderate
Infliximab and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress immune function through different pathways, so combined use may increase the risk of serious infection. The risk persists as B-cell depletion lasts for months.
What this interaction means in plain words
Infliximab and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Infliximab belongs to Musculoskeletal; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from TNF-alpha blockade and anti-CD20 B-cell depletion.
What to do
Monitor closely for infection and screen for hepatitis B and tuberculosis before therapy. Avoid the combination unless clearly justified.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Ublituximab
Frequently asked questions
Can I take Infliximab with Ublituximab?
MediHelp rates the interaction as moderate. Infliximab and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress immune function through different pathways, so combined use may increase the risk of serious infection. The risk persists as B-cell depletion lasts for months.
How serious is the interaction between Infliximab and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for infection and screen for hepatitis B and tuberculosis before therapy. Avoid the combination unless clearly justified.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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