Drug interactions
Influenza virus vaccine adjuvanted + Lomustine
Severity: Moderate
Influenza virus vaccine adjuvanted and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine-induced immunosuppression may weaken the response to the adjuvanted H5N1 influenza vaccine, although adjuvant may partly compensate.
What this interaction means in plain words
Influenza virus vaccine adjuvanted and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic suppression of lymphocytes and bone marrow reduces vaccine-induced immune response.
What to do
Vaccinate at least 2 weeks before lomustine when possible; otherwise consider revaccination about 3 months after therapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Influenza virus vaccine adjuvanted and Lomustine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine adjuvanted with Lomustine?
MediHelp rates the interaction as moderate. Influenza virus vaccine adjuvanted and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine-induced immunosuppression may weaken the response to the adjuvanted H5N1 influenza vaccine, although adjuvant may partly compensate.
How serious is the interaction between Influenza virus vaccine adjuvanted and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before lomustine when possible; otherwise consider revaccination about 3 months after therapy ends.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
