Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Leflunomide
Severity: Minor
Influenza virus vaccine quadrivalent adjuvanted and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide may reduce antibody responses to influenza vaccination. The inactivated vaccine is still safe and recommended, though protection may be diminished.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Leflunomide suppresses lymphocyte proliferation, which can blunt vaccine-induced antibody production.
What to do
Vaccinate as recommended without interrupting leflunomide; do not withhold the vaccine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Leflunomide?
MediHelp rates the interaction as minor. Influenza virus vaccine quadrivalent adjuvanted and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leflunomide may reduce antibody responses to influenza vaccination. The inactivated vaccine is still safe and recommended, though protection may be diminished.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as recommended without interrupting leflunomide; do not withhold the vaccine.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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