Drug interactions
Influenza virus vaccine quadrivalent recombinant + Leflunomide
Severity: Minor
Influenza virus vaccine quadrivalent recombinant and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide is immunosuppressive and may blunt the antibody response to influenza vaccination. The recombinant vaccine is non-live, so it is safe to give, but protection may be reduced.
What this interaction means in plain words
Influenza virus vaccine quadrivalent recombinant and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Leflunomide inhibits lymphocyte proliferation through DHODH inhibition, which may reduce vaccine immunogenicity.
What to do
Give the vaccine as recommended and do not withhold it. Do not rely on an adequate response and maintain other preventive measures.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent recombinant with Leflunomide?
MediHelp rates the interaction as minor. Influenza virus vaccine quadrivalent recombinant and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leflunomide is immunosuppressive and may blunt the antibody response to influenza vaccination. The recombinant vaccine is non-live, so it is safe to give, but protection may be reduced.
How serious is the interaction between Influenza virus vaccine quadrivalent recombinant and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine as recommended and do not withhold it. Do not rely on an adequate response and maintain other preventive measures.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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