Drug interactions
Influenza virus vaccine quadrivalent recombinant + Secukinumab
Severity: Minor
Influenza virus vaccine quadrivalent recombinant and Secukinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inactivated vaccines are not contraindicated with secukinumab, but the antibody response may be reduced in treated patients. Secukinumab has been shown to permit adequate responses to inactivated influenza vaccine, so the effect is likely modest.
What this interaction means in plain words
Influenza virus vaccine quadrivalent recombinant and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
IL-17A inhibition may modestly blunt immune responses, though humoral responses to non-live vaccines are largely preserved.
What to do
Give influenza vaccine as indicated, ideally before starting secukinumab; no interruption of therapy is generally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent recombinant with Secukinumab?
MediHelp rates the interaction as minor. Influenza virus vaccine quadrivalent recombinant and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inactivated vaccines are not contraindicated with secukinumab, but the antibody response may be reduced in treated patients. Secukinumab has been shown to permit adequate responses to inactivated influenza vaccine, so the effect is likely modest.
How serious is the interaction between Influenza virus vaccine quadrivalent recombinant and Secukinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give influenza vaccine as indicated, ideally before starting secukinumab; no interruption of therapy is generally required.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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