Drug interactions
Influenza virus vaccine trivalent + Lomustine
Severity: Moderate
Influenza virus vaccine trivalent and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy with lomustine can blunt antibody responses to inactivated trivalent influenza vaccine, leaving patients with reduced protection.
What this interaction means in plain words
Influenza virus vaccine trivalent and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic suppression of lymphocytes and bone marrow reduces vaccine-induced immune response.
What to do
Vaccinate ideally at least 2 weeks before lomustine or between cycles when counts have recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine trivalent with Lomustine?
MediHelp rates the interaction as moderate. Influenza virus vaccine trivalent and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy with lomustine can blunt antibody responses to inactivated trivalent influenza vaccine, leaving patients with reduced protection.
How serious is the interaction between Influenza virus vaccine trivalent and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally at least 2 weeks before lomustine or between cycles when counts have recovered.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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