Drug interactions
Insulin aspart-insulin aspart protamine + Sotagliflozin
Severity: Moderate
Insulin aspart-insulin aspart protamine and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin on top of insulin lowers glucose further and increases hypoglycemia risk. Diabetic ketoacidosis is also a concern with this drug.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart-insulin aspart protamine belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering through SGLT inhibition and urinary glucose loss.
What to do
Consider a modest insulin dose reduction when starting sotagliflozin and monitor glucose. Check ketones if symptoms of ketoacidosis develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Sotagliflozin?
MediHelp rates the interaction as moderate. Insulin aspart-insulin aspart protamine and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin on top of insulin lowers glucose further and increases hypoglycemia risk. Diabetic ketoacidosis is also a concern with this drug.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a modest insulin dose reduction when starting sotagliflozin and monitor glucose. Check ketones if symptoms of ketoacidosis develop.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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