Drug interactions
Insulin aspart protamine / insulin aspart + Metoclopramide
Severity: Moderate
Insulin aspart protamine / insulin aspart and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide accelerates gastric emptying, so food reaches the intestine and glucose is absorbed earlier. This can mismatch insulin action with glucose rise, causing altered glycemic control in patients with diabetic gastroparesis.
What this interaction means in plain words
Insulin aspart protamine / insulin aspart and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Faster gastric emptying changes the timing of carbohydrate absorption relative to insulin action.
What to do
Monitor blood glucose closely and adjust insulin dose or timing when metoclopramide is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Insulin aspart protamine / insulin aspart with Metoclopramide?
MediHelp rates the interaction as moderate. Insulin aspart protamine / insulin aspart and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide accelerates gastric emptying, so food reaches the intestine and glucose is absorbed earlier. This can mismatch insulin action with glucose rise, causing altered glycemic control in patients with diabetic gastroparesis.
How serious is the interaction between Insulin aspart protamine / insulin aspart and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and adjust insulin dose or timing when metoclopramide is started or stopped.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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