Drug interactions
Insulin degludec + Metolazone
Severity: Moderate
Insulin degludec and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-like diuretics can raise blood glucose and reduce glycemic control in patients with diabetes. Insulin requirements may increase after metolazone is started.
What this interaction means in plain words
Insulin degludec and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity cause hyperglycemia, opposing insulin action.
What to do
Monitor blood glucose after starting or changing metolazone and adjust insulin degludec dose if needed. Keep serum potassium normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec and Metolazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metolazone
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Metolazone?
MediHelp rates the interaction as moderate. Insulin degludec and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-like diuretics can raise blood glucose and reduce glycemic control in patients with diabetes. Insulin requirements may increase after metolazone is started.
How serious is the interaction between Insulin degludec and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing metolazone and adjust insulin degludec dose if needed. Keep serum potassium normal.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
