Drug interactions
Insulin degludec + Sotalol
Severity: Moderate
Insulin degludec and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers such as sotalol can mask adrenergic symptoms of hypoglycemia and may delay glucose recovery. They can also occasionally worsen glycemic control.
What this interaction means in plain words
Insulin degludec and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Sotalol belongs to Cardiovascular.
Why it happens
Beta-adrenergic blockade impairs glycogenolysis and counter-regulation and blunts autonomic hypoglycemia symptoms.
What to do
Monitor blood glucose more frequently when starting or changing sotalol and counsel the patient that hypoglycemia may be less noticeable. Adjust insulin dosing as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Sotalol?
MediHelp rates the interaction as moderate. Insulin degludec and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers such as sotalol can mask adrenergic symptoms of hypoglycemia and may delay glucose recovery. They can also occasionally worsen glycemic control.
How serious is the interaction between Insulin degludec and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or changing sotalol and counsel the patient that hypoglycemia may be less noticeable. Adjust insulin dosing as needed.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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