Drug interactions
Insulin degludec / insulin aspart + Medroxyprogesterone
Severity: Moderate
Insulin degludec / insulin aspart and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can impair glucose tolerance and reduce insulin sensitivity, which may raise insulin requirements. Glycemic control may worsen when medroxyprogesterone is started.
What this interaction means in plain words
Insulin degludec / insulin aspart and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through progestin-induced insulin resistance.
What to do
Monitor blood glucose more frequently after starting or changing medroxyprogesterone and titrate insulin as needed. Re-check doses if the progestin is stopped to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Progestins can impair glucose tolerance and reduce insulin sensitivity, which may raise insulin requirements. Glycemic control may worsen when medroxyprogesterone is started.
How serious is the interaction between Insulin degludec / insulin aspart and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting or changing medroxyprogesterone and titrate insulin as needed. Re-check doses if the progestin is stopped to avoid hypoglycemia.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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