Drug interactions
Insulin degludec-insulin aspart + Nateglinide
Severity: Moderate
Insulin degludec-insulin aspart and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining nateglinide with insulin gives additive glucose lowering and a higher risk of hypoglycemia. The risk is greatest if meals are delayed or skipped.
What this interaction means in plain words
Insulin degludec-insulin aspart and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: nateglinide stimulates endogenous insulin release on top of exogenous insulin.
What to do
Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs. Advise taking nateglinide only with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Nateglinide?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining nateglinide with insulin gives additive glucose lowering and a higher risk of hypoglycemia. The risk is greatest if meals are delayed or skipped.
How serious is the interaction between Insulin degludec-insulin aspart and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs. Advise taking nateglinide only with meals.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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